|Series||Scooby-Doo! Mystery Incorporated|
|Location||Mystery Incorporated Clubhouse|
|Voiced by||Grey DeLisle|
|“||Danger-prone Daphne does it again!||”|
Daphne Blake was one of the founding members of Mystery Inc. "Daph" has a remarkably changeable personality. At times, she can be quite intelligent (though hardly a genius like Velma), but she can also be ditzy, wacky, a bit of a klutz, and too inclined to rely on what she calls her "feminine intuition." Being fabulously wealthy and extremely attractive physically, she can be a bit vain, and even a bit selfish on occasion; but she is also fiercely loyal, friendly, and helpful toward people in need. She can sometimes be a helpless damsel-in-distress, quite self-reliant, and then again, she can be fiercely independent.
Daphne has a crush on Fred Jones and is frustrated when he is oblivious to her affection.
Daphne and Fred are investigating the area where the Mystery Incorporated Clubhouse stands, as numerous people have reported that it is haunted by a Green Phantom Hound with glowing red eyes. Shaggy is there as well, trying to find out what happened to Scooby-Doo.
Daphne once ditched Gwen Tennyson to go to a concert. She had told Gwen that she had no tickets, but, when Fred showed up with two extras, she invited Shaggy to go instead of Gwen (claiming that she couldn't call because her cell phone was broken), and even wore Gwen's T-shirt there! As a result, Gwen deliberately set her up with Eddy, who has a tendency to pester her in the game.
- Daphne's interaction with Gwen and Eddy comes from the "Toonface" series of bumpers, in which the story of Daphne at the Arka Medeze concert occurs.